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Pulmonary Hypertension Pulmonary hypertension is elevated pressure in the pulmonary arteries that carry blood from the lungs to the heart. As pulmonary hypertension worsens, some people with the condition have difficulty performing any activities that require physical exertion.

While there is no cure for pulmonary hypertension, it can be managed and treated with medications and supplemental oxygen to increase blood oxygen levels. Multiple Sclerosis Multiple sclerosis symptoms vary from person to person, and can last for days to months without periods of remission. Treatment options for multiple sclerosis vary depending on the type and severity of symptoms. Scleroderma Scleroderma is an autoimmune disease of the connective tissue. Treatment of scleroderma is directed toward the individual features that are most troubling to the patient. Eating healthy, exercise, managing stress, and knowing when to have medical tests for a particular age is key to disease prevention in men.

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Sexual Problems in Women Sexual dysfunction refers to a problem that arises during any phase of the sexual response cycle, preventing an individual or couple from experiencing sexual satisfaction. Sex, Urinary, and Bladder Problems of Diabetes Having diabetes can mean early onset and increased severity of bladder symptoms and changes in sexual function. Men may have erectile dysfunction; and women may have problems with sexual response and vaginal lubrication. Keep your diabetes under control, and you can lower your risk of sexual and urologic problems.

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Senior Sex Enjoying a satisfying sex life as we age is important to both physical and mental health. As we age, diseases and conditions may pose challenges in our sexual health, and sexual experiences. Learn how to manage your conditions and still have a gratifying sex life as you age. Buying medication online can have risks when the source is not reputable.

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In patients with severe renal impairment (creatinine clearance less than 30 mL/minute), the initial sildenafil dose for the treatment of ED should be decreased to 25 mg, since the drug’s effects may be prolonged and enhanced in such patients. In a study in patients with PAH who were receiving stable dosages of sildenafil , administration of single doses of riociguat resulted in additive hemodynamic effects. Reported hearing loss was unilateral in most cases, and temporary in about one-third of the cases. In one case, a 44-year-old man experienced permanent, bilateral sensorineural deafness 15 days after initiating therapy with sildenafil 50 mg daily; this patient did not have any prior or current risk factors for ototoxicity.

Common sexual problems in men include erectile dysfunction , premature ejaculation, and loss of libido. Peyronie’s Disease Peyronie’s disease or curvature of the penis is a condition in which scar tissue develops inside the penis. There is no cure for Peyronie’s disease, however, there are medications that can reduce symptoms of the disease. Erectile Dysfunction Erectile dysfunction is the failure to achieve or maintain an erection.

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You’ll need to talk to your healthcare provider if you’re considering either, as they have the same drug interactions, including nitrates . Pretreatment with saquinavir (1200-mg liquid-filled capsules 3 times daily) or ritonavir followed by a single dose of sildenafil increased sildenafil’s AUCs by 210 or 1000%, respectively, and the peak plasma concentrations by 140 or 300%, respectively. Ritonavir is a potent inhibitor of both the major and minor metabolic pathways for sildenafil, while saquinavir is a relatively weak inhibitor of CYP3A4 , with little inhibitory activity against CYP2C9.

  • Reported hearing loss was unilateral in most cases, and temporary in about one-third of the cases.
  • In a study in patients with PAH who were receiving stable dosages of sildenafil , administration of single doses of riociguat resulted in additive hemodynamic effects.
  • In patients with severe renal impairment (creatinine clearance less than 30 mL/minute), the initial sildenafil dose for the treatment of ED should be decreased to 25 mg, since the drug’s effects may be prolonged and enhanced in such patients.

Counterfeit PDE5i can have variable amounts of the active drug ranging from 0%–200+% of the drug. In cases where the active ingredient is present in lower amounts than expected, this can mean lack of effectiveness even though the same dose of active drug may work well in a given individual.

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